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In GLP-1 (737) NH 2 , both the affinity and activity are slightly promoted when Val 16 is replaced with Tyr 16 .28 Thus, the Tyr 10 in tirzepatide may have a positive influence on both GLP-1 and GIP activity

Effects of exogenous glucagon-like peptide-1 on blood pressure, heart rate, gastric emptying, mesenteric blood flow and glycaemic responses to oral glucose in older individuals with normal glucose tolerance or type 2 diabetes

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