Conversely, some case reports for exenatide 181 and semaglutide 182 described onset or relapse of depressive symptoms, which resolved when the GLP-1RAs were stopped 181,182 and recurred on medication rechallenge 181
Store the sealed lyophilized vial cool, dry, and away from light, and refrigerate it once reconstituted
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Depression is associated with reductions in brain volume, and there are volumetric changes in various brain regions including the hippocampus, amygdala, prefrontal cortex, anterior cingulate, and basal ganglia