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Beyond the regulation of food intake, body weight and energy expenditure, POMC neurons directly respond to certain types of fatty acids and control hepatic glucose production, insulin sensitivity, glucose and lipid metabolism, illustrating their critical role in overseeing whole body use of energy substrates and consequent involvement in metabolic disorders [98, 122,123,124,125,126]

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This activity partly antagonizes the GIP lipogenic effect and translates clinically into weight loss exceeding tirzepatide's

Influence of long-term, low-dose, diuretic-based, antihypertensive therapy on glucose, lipid, uric acid, and potassium levels in older men and women with isolated systolic hypertension: the Systolic Hypertension in the Elderly Program

Molecular link between vitamin D and cancer prevention