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4.1.8 lyotropic liquid crystalline lipid nanoparticles (LLCNP) Lyotropic liquid crystalline lipid nanoparticles (LLCNPs) have recently emerged as an additional class of lipid-based nanocarriers with relevance to drug and gene delivery, including RNA-based delivery

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Female 8-12-week-old C57BL6/NCrl mice (Charles River, Wilmington, MA) were acclimated for one week, then randomized to either a 60 kcal% high-fat diet (Research Diets D12492, New Brunswick, NJ) or an isonutrient-matched control diet with 10 kcal% fat (Research Diets D12450J) for 1520 weeks to generate control (nonobese) and diet-induced obese (DIO) phenotypes, respectively