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Kechagia, J
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Abbreviations AC: Adenylate cyclase AMPK: Adenosine monophosphate-activated protein kinase cAMP: Cyclic adenosine monophosphate CREB: cAMP response element binding protein CREBBP: CREB binding protein ERK: Extracellular signal-regulated kinase ER: Estrogen receptor Alpha (gene Esr1 ) EVs: Extracellular vesicles FG: Fasting glucose GABA: Gamma-aminobutyric acid GFP: Green fluorescent protein GH: Growth hormone GHD: Growth hormone deficiency GHR: Growth hormone receptor GHRH: Growth hormone releasing hormone GHRHR: Growth hormone releasing hormone receptor GHSR: Growth hormone secretagogue receptor HDL: High-density lipoprotein HIV: Human immunodeficiency virus icv: Intracerebroventricular IGF1: Insulin-like growth factor 1 IGFBP3: Insulin-like growth factor binding protein 3 IGF1R: Insulin-like growth factor 1 receptor iv: Intravenous MAPK: Mitogen-activated protein kinase MASLD: Metabolic dysfunction associated steatotic liver disease OGTT: Oral glucose tolerance test PIT1: Pituitary transcription factor 1 PKA: Protein kinase A rhGH: Recombinant human growth hormone SST: Somatostatin SSTR1: Somatostatin receptor 1 SSTR2: Somatostatin receptor 2 SSTR5: Somatostatin receptor 5 TH: Tyrosine hydroxylase References Guillemin R, et al
Our work suggests that GIPR antagonism does not require the central production of GLP-1, as ablation of the Ppg neuron population had little effect on the weight loss outcomes
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