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Accuracy of Surrogate Matrix Fortified plasma samples were prepared from three different lots of plasma and analyzed using calibrators prepared in BSA to test the accuracy of using BSA as a surrogate matrix for underivatized acylcarnitines analysis

Commonly used activators include HOBt (1-hydroxybenzotriazole), HBTU (2- (4-hydroxyphenyl) -4,5-dihydro-4-methyl-6-nitroimidazolo [1,2-a] pyridine-3-one), TBTU (2- (2-pyridyldithio) benzotriazole sodium salt), etc

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1 Irrespective of the specific urate-lowering therapy (ULT) selected, fundamental principles entail commencing treatment concurrently with prophylaxis and initiating with a conservative dosage, followed by systematic monitoring of serum uric acid levels and subsequent dose adjustment until the therapeutic target is attained

Extensive analysis of the T315I substitution and detection of additional ABL mutations in progenitors and primitive stem cell compartment in a patient with tyrosine kinase inhibitor-resistant chronic myeloid leukemia