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[DOI] [PubMed] [Google Scholar] Stephan KE, Baldeweg T, Friston KJ

[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Jakubowska A., Le Roux C.W., Viljoen A

Although challenges such as limited bioavailability and safety concerns continue to impede clinical translation, these limitations may be addressed through the optimization of delivery strategies, rigorous pharmacokinetic and toxicological assessments, mechanism-driven in vitro , in vivo , ex vivo studies, and well-designed clinical trials

300,301 Recent findings suggest that exposure to certain environmental factors such as pesticides can augment astrocyte proinflammatory signalling and thereby promote CNS autoimmune inflammation