Alcohol-associated PAGln production and cardiovascular dysfunction are transmissible traits To address the relative contribution of alcohol-induced gut microbial reorganization towards increased PAGln levels and subsequent cardiovascular dysfunction, we performed microbial transplantation of gut commensals from PF and AF mice into nave mice using a previously reported protocol with modifications as described (Fig
With decreased gastric emptying and increased satiety, a common pharmacological effect observed when conducting these studies is a decrease in food consumption and body weight loss
Recent research has investigated microbiota-based therapeutics in ameliorating autophagy through modulating endogenous GLP-1 as a potential method to mediate AD and PD symptomology (Bonfili et al ., Reference Bonfili, Cecarini, Berardi, Scarpona, Suchodolski, Nasuti, Fiorini, Boarelli, Rossi and Eleuteri2017
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Leitch JM, Li CX, Baron JA, Matthews LM, Cao X, Hart PJ, Culotta VC