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At the time of writing, phase II clinical trials are underway for some of these agents with negative results in INVOKE-2 trial (van Lengerich et al., 2023

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Table of Contents How Weight Loss Medications Can Affect Kidney Health Which Options Are Considered Safer for People With Kidney Conditions NICE and MHRA Guidance on Weight Management With Renal Impairment When to Speak to Your GP or Renal Specialist Before Starting Treatment Lifestyle Approaches to Weight Loss That Support Kidney Health Scientific References Frequently Asked Questions How Weight Loss Medications Can Affect Kidney Health Weight loss medications work through a variety of mechanisms from suppressing appetite and reducing fat absorption to mimicking gut hormones that regulate blood sugar and satiety

doi: 10.1080/00365521.2022.2041084 13 HalimMADegerbladMSundbomMKarlbomUHolstJJWebbD-Let al

From my clinical observations, patients on SGLT2 inhibitors often experience reduced fluid retention and lower blood pressure without the electrolyte imbalances commonly seen with stronger diuretics