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Neuroinflammation and hypothalamicpituitaryadrenal axis Neuroinflammation consists of an inflammatory process within the brain or spinal cord, mediated by cytokines, chemokines, free radicals and other active ligands

Studies with olanzapine-induced obesity in rodents also demonstrated weight loss after exposure to betahistine (138)

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These bidirectional interactions converge in a conceptual framework known as the gut-brain axis, emphasising the deep interdependence of the two systems [76]

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