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Previous studies reported elevated Met level in patients with obstructive cholestasis, suggesting a potential link between Met and BA

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CrossRef White adipose tissue browning in critical illness: A review of the evidence, mechanisms and future perspectives Elham Alipoor, Mohammad Javad HosseinzadehAttar, Mahsa Rezaei, Shima Jazayeri, Marianne Chapman Obesity Reviews.2020;[Epub] CrossRef Metabolic and energetic benefits of microRNA-22 inhibition Marc Thibonnier, Christine Esau, Sujoy Ghosh, Edward Wargent, Claire Stocker BMJ Open Diabetes Research & Care.2020

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doi: 10.1016/j.diabres.2017.01.012 5 SzadkowskaAMadejAZiolkowskaKSzymanskaMJeziornyKMianowskaBet al

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G119S substitution results in steric hindrance, which reduces substrate or inhibitor binding, whereas F290V and F331W both modify the stabilisation process [84]

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