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Heck and coauthors (Van den Heuvel and Heck, 2004)) into a powerful analytical technique for structural biology

Ebert, S.M

4.4 Interactions between cartilage and synovium 4.4.1 Interplay between cytokines released by chondrocytes and synovial cells When cartilage is damaged, chondrocytes release proteoglycan fragments, type II collagen fragments, and diverse injury-associated factors that synovial cell surface pattern recognition receptors (PRRs) can detect, prompting synovial hyperplasia and proinflammatory cytokine secretion (139)

This systems activity declines with aging, and GHK-Cus restoration of proteasome function likely contributes to its anti-aging effects at the cellular level

Bao, R., Zhang, Y., Lou, X., Zhou, C.Z