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477 proteins were found to be differentially expressed (Supplemental Table 1), of which 302 proteins had a minimum fold change of 1.2 (Supplemental Table 2)

Notably, brain-resident astrocytes and microglia might also be susceptible to EBV infection, which would greatly broaden the potential source of deleterious viral products and downstream effects, including reactivation of retroviral elements such as HERV-W (Hassani et al., 2018)

Conclusion IGF-1 is a master regulator of protein, RNA and DNA synthesis and is involved in Ca 2+ signaling that regulates synaptogenesis, neurite and glial (astrocytes, oligodendrocytes, schwann cells and microglia) proliferation and repair

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This results in excessive formation of the dipeptide -glutamylcysteine, which is converted by -glutamyl cyclotransferase into 5-oxoproline