b) reacting compound of formula-22 with compound of formula-23 in a solvent optionally in presence of a base to provide compound of formula-24, The solvent in step-a) to step-d) wherever necessary is selected from hydrocarbon solvents, ether solvents, ester solvents, polar-aprotic solvents, chloro solvents, ketone solvents, nitrile solvents, water and the like or mixtures thereof
[6] The rapid pace leaves less time for metabolic adaptation, making proactive muscle and bone protection through myHMB and calcium supplementation critical rather than optional
Step 3: Preparation of compound of formula-12 Acetonitrile (150 ml) was added to compound obtained in step 2 at 25-30C and stirred for 10 min
DIPEA (10.5 ml) was slowly added to the reaction mixture at 0-5C and stirred for 30 min at the same temperature
The dose in milligrams always equals the concentration divided by 10 when you draw 10 units