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We have therefore established a link between a metabolic switch in response to GSH loss to the inability to mount antibody-mediated immune responses in vivo

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This induction often occurs via activation of Nrf2 (Nuclear factor erythroid 2-related factor 2), a key transcription factor in the antioxidant response pathway

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Prenatal exposuresincluding fever, infections, and medications like Tylenolmay contribute for some children, especially in the context of specific genetic profiles and co-exposures