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Improved cardiovascular outcomes: As a GLP-1 agonist, Ozempic has been associated with decreased cardiovascular risk factors

What the Clinical Data Actually Shows The most definitive comparison comes from the SURMOUNT-5 trial, a direct head-to-head study published in the New England Journal of Medicine comparing tirzepatide 10 mg and 15 mg against semaglutide 2.4 mg in adults with obesity but without diabetes

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30,31 On one hand, neuro-signals mediated by GLP-1 activation regulate food intake by controlling appetite and satiety and modulate endocrine organs like the pancreas, thus affecting overall metabolism