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Research over the past two decades has shown that microbiome composition can influence: Energy extraction from food Fat storage signaling Immune activity Hormone production related to appetite Some microbial populations are associated with increased energy harvest from dietary carbohydrates, which may contribute to weight gain in certain individuals

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Inadequacy of macro-nutrients is just one cause of fatigue, and pumping yourself with Vitamin B12 shots will not help if the root cause is unrelated to B12 deficiency

Further research is required in order to compare realistic vaccination pathways amid immune escape

There were both prophylactic and therapy effects