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Machine learning models trained on network pharmacology data can predict which herbal combinations are most likely to act synergistically on complex diseases like IBD

A 2014 mouse study found that NAC and vitamin E accelerated lung tumor progression and reduced survival.41 A 2015 melanoma mouse study found that NAC increased lymph node metastases in mice with malignant melanoma.42 A 2019 mouse study reported that NAC protected against emphysema-related lung damage but also induced lung adenocarcinoma in some mice.43 And a 2021 hepatocellular carcinoma study found that antioxidant supplements including NAC promoted tumor formation, growth, and drug resistance in experimental models by reducing intracellular ROS.3 Newer human data add another layer of complexity

Cham, Switzerland: Springer Nature

2022;8:eabo4271

Inhibitor (2 l) was added to a 96 well microplate in triplicate for each NADPH and inhibitor concentration, and 192 l of the master buffer was added to each well