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[2] Adherence to the prescribed treatment regimen is essential for optimal outcomes

Importantly, a clinical study has demonstrated that combining radiotherapy with higher doses of the TGF-blocking antibody fresolimumab (10 mg/kg) increases overall survival significantly in metastatic breast cancer patients compared to those undergoing radiotherapy and receiving lower doses of fresolimumab (1 mg/kg) [135]

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Even activities as simple as reading a book or sleeping with the fingers and wrist flexed may contribute to symptoms