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Morphine-associated contextual cues induce structural plasticity in Hippocampal CA1 pyramidal neurons

Bioavailability is usually determined by calculating the respective plasma drug exposure assessed as the total area under the drug plasma concentration versus time curve (AUC) after oral and intravenous administration as: In general, determinants of oral drug bioavailability include fraction of dose absorbed in the gastrointestinal tract (GIT) and fraction of dose that escapes elimination by the intestinal tract, liver, and lung

Another form of vesicular transport pinocytosis, which is responsible for the transport of fluids across cells, is largely lacking in the BBB [25]