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Who should be cautious: People with thyroid disorders or those who are pregnant, nursing, or on medications should discuss use with a healthcare provider before use

sativa key compound, acts as a partial agonist to the cannabinoid receptors CB1 and CB2 (Mecha et al., 2020), displaying anti-inflammatory and neuroprotective properties, suppressing the IFN, IL-17, IL-6, IL-1, and TNF- production in the brain and preventing the infiltration of immune cells into the CNS

In DPN, particularly omega-3s, demonstrate protective mechanisms through the anti-inflammatory effect, antioxidant pathways (mostly Nrf2 pathway), membrane stability and improved conduction velocity [113]

Additionally, in one animal study, -linolenic acid (a plant-derived omega-3 fatty acid) suppressed expression of adhesion molecules , which are important in inflammation, immune responses and in intracellular signaling events (Golias 2011