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J Biol Chem (2005) 280:456877

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It must not be used by individuals who have a personal or family history of a rare thyroid cancer (medullary carcinoma) or multiple endocrine neoplasia syndrome type 2 (MEN2)

The method of any one of embodiments 1-10, wherein the therapeutic agent is a TRPV modulator

Truncation studies showed that the membrane proximal 61 amino acids of GP130 are sufficient for signal transduction (68), and later it was shown for GHR that the membrane proximal 20 residues (which includes the Box1 motif) of the ICD is sufficient for JAK2 binding, but not sufficient for GH-induced activation of JAK2 (69)