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Common side effects include nausea, vomiting, and gastrointestinal discomfort, which may temporarily reduce sexual interest

Appetite control, improved metabolic regulation, and reduced food noise typically come first

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Managing Side Effects During the First Few Weeks As these medications slow digestion, it's common to experience temporary side effects at the beginning, including: Nausea Heartburn Constipation Feeling overly full Fortunately, these symptoms are usually manageable

This analysis demonstrated that GI side effects occurred in 37.6% of participants receiving semaglutide plus metformin, compared to 40.3% of those receiving semaglutide alone