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Similarly, in SURMOUNT-4 (tirzepatide), participants completed a 36-week open-label lead-in to 10 or 15 mg, after which they were randomized to continue tirzepatide or switch abruptly to placebo

Clinical Pharmacology & Therapeutics, 38(2), 141-147

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The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node

The proposed chain of effects looks like this: NNMT inhibited nicotinamide is no longer inactivated by methylation and becomes available for conversion to NAD+