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Participants were randomly assigned in a 1:1:1:3 ratio to receive subcutaneous injections of tirzepatide once per week at doses of 5 mg, 10 mg, or 15 mg, or insulin glargine (100 U/mL)

Two brain regions that have GLP-1 receptors present are the ventral tegmental area and nucleus accumbens, which happen to be critical in the development of substance use disorders, where addictive substances hijack natural reward pathways, leading to compulsive behaviors

Pharmacol Rev (2008) 60(4):470512

An injection delivers it into the muscle for steady absorption, sidestepping that problem and making the shot a more practical way to take it

A boiled egg or cottage cheese on wholegrain toast can go a long way