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DNA damage uncouples the mitogenic response to IGF-I in MCF-7 malignant breast cancer cells by switching the roles of PI3 kinase and p21WAF1/Cip1

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Successful clinical trials of MI show that it may have the ability to be a low-risk alternative to complement the use of the mammography technique in diagnosing breast cancer (170)

, effect of a single AOX, or of a specific time of assessment), without analyzing the overall effect (hence, independently from the time and the specific AOX used)

Similarly, other large trials have shown neutral results for cardiovascular endpoints