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Approximate equivalency chart These are rough guidelines based on clinical observation, not precise conversions: Semaglutide 0.25-0.5mg corresponds roughly to tirzepatide 2.5-5mg Semaglutide 1mg corresponds roughly to tirzepatide 5-7.5mg Semaglutide 1.7mg corresponds roughly to tirzepatide 7.5-10mg Semaglutide 2.4mg corresponds roughly to tirzepatide 10-15mg These equivalencies suggest where you might eventually land, not where you should start

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Heavier individuals may require higher doses to achieve equivalent NNMT inhibition due to larger adipose tissue mass and potentially higher baseline NNMT activity

Side effects : Nausea, vomiting, and pancreatitis are common