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However, rapid fat loss can come with unwanted lean-mass reduction (up to 25-39% of total weight loss) as fat-free mass in some trials

One such condition is Glutathione Synthetase Deficiency (GSD), a rare metabolic disorder that can present with severe symptoms

GLP-1s can lead to rapid weight loss, increasing the risk of muscle atrophy

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When to seek urgent medical attention : Severe, persistent abdominal pain that does not resolve (if pancreatitis is suspected, stop taking the medication and seek immediate medical assessment) Signs of dehydration from persistent vomiting or diarrhoea (which can lead to acute kidney injury) Allergic reactions (rash, difficulty breathing, swelling of face or throat) Symptoms of hypoglycaemia if taking other glucose-lowering medications (shakiness, confusion, sweating) Regular follow-up with your healthcare team is essential to monitor your response to treatment, adjust doses appropriately, and address any concerns promptly