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"Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency." Proceedings of the National Academy of Sciences , 103(6), 17681773

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Results: Berberine reduced renal injury in STZ-induced DN rat model, as evidenced by the decrease in fasting blood glucose, ratio of kidney weight to body weight, 24-h urinary protein, serum creatinine, and blood urine nitrogen