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Experiments ex vivo have shown that vinpocetine acts as a selective inhibitor of Ca 2+ /calmodulin-dependent cyclic nucleotide phosphodiesterase type I [21,108], a potent blocker of voltage-gated sodium channels [109,110], inhibits platelet aggregation, reduces blood viscosity, vasodilates cerebral arteries, and increases cerebral blood flow [111]
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They are rapidly inactivated by dipeptidyl peptidase-4 (DPP-4)
They operate through specific, well-documented pathways
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