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285 , R470R478 (2003)

The inhibition of SGLT2 decreases the expression of HIF-1 in human proximal tubules under hypoxic conditions, leading to a reduction in tubular damage and interstitial fibrosis (274, 275)

Administration of GSH precursors like cysteine/N-acetylcysteine, glycine and/or glutamic acid will facilitate the synthesis of GSH within each cell of the body including the atherosclerotic plaque, reducing ROS and LDL oxidation, enhancing NO production, and mitigating atherosclerosis and its complications (221229)

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