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In trials where semaglutide tablets was added on to metformin and/or sulfonylurea, basal insulin alone, or metformin in combination with basal insulin in patients with moderate renal impairment, severe hypoglycemia was not reported in any of the patients in the trial

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In a departure from other contemporaneous guidelines, ESSIC recommended that classification of BPS types might be performed according to findings at cystoscopy with hydrodistention, as well as histologic findings in bladder biopsies ( Box 35.2 )