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Further research is required to comprehensively understand tirzepatides impact on vasodilation and its precise effects on cardiovascular function

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GLP-1 medications also carry an FDA black box warning for risk of thyroid C-cell tumors, and should not be used by patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 (MEN2)

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Therapeutic benefits to the cardiovascular and renal systems are emerging yet it currently remains unresolved if these are via direct actions on GLP-1R on these tissues or an indirect effect mediated by the health benefits of weight loss