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It has been shown that SIRT1 prevents the development of endothelial dysfunction through attenuation progression of oxidative stress by multiple mechanisms including SIRT1/SOD, SIRT1/FOXO, SIRT1/eNOs, and SIRT1/NF-B (Kang et al

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Chen Y, Deng J, Fujimoto J, Kadara H, Men T, Lotan D, et al