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However, taurine does not increase the activity of other complexes except complex I in the ETC in overuse muscle, suggesting that taurine prevents ROS production at the complex I level (Figure 2)

These residues are located at the base of the GLP-1R binding pocket in the cryo-EM structures and interact with residues in TMs 1, 2 and 7 (Figures 2 & 3, Supplemental Figure 4, Supplemental Table 3)

Potential muscle loss : GLP-1s can cause lean mass loss alongside fat loss

Under homeostatic conditions, transient activation of NRF2 is cytoprotective, allowing for adaptation to various cell intrinsic (i.e., reactive oxygen species (ROS) generated by mitochondrial function) and extrinsic (i.e., xenobiotic) stressors (Kensler et al, 2007

This distinction is clinically important: true GLP-1 agonists like semaglutide and tirzepatide create systemic effects on appetite, gastric motility, and insulin secretion