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Similar, but larger, movements are observed upon channel opening 27 , suggesting that the binding of a single atorvastatin (per protomer) to RyR1 in a closed conformation may prime the channel for opening

Can Res 54(9):23902397 Steinmetz KA, Kushi LH, Bostick RM, Folsom AR, Potter JD (1994) Vegetables, fruit, and colon cancer in the lowa womens health study

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The structure of C-RTC in complex with the essential nsp13 helicase and RNA suggests that the helicase can facilitate the backtracking mechanism 136 (Fig

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