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Audit your list and check your state every time you consider adding something new

Toxicity of Aflatoxin B1 towards the Vitamin D Receptor (VDR). Food and Chemical Toxicology 76 (February 2015): 7779

The short answer: it depends on the specific formula

Public Health Service Policy on Humane Care and Use of Laboratory Animals and the Guide for the Care and Use of Laboratory Animals (National Research Council, 8th edition, 2011)

So a lot of people complain about insomnia, they complain about their heart racing or heart palpitations, various things like that, overstimulation, feeling like the lights are too bright or the sounds are too strong or whatever