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This is because its a low dose to help your body get used to the medication

Poor sleep increases cortisol, drives insulin resistance, increases hunger hormones (even partially overriding GLP-1 appetite suppression), and impairs recovery from exercise

When Paclitaxel and Doxorubicin were injected into a mouse model of breast-to-brain metastases, the BTB displayed greater overall permeability than intact BBB, and there was considerable variability in compound distribution between and within the various metastases, with some lesions showing compound concentration differences as high as 200 fold 35