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Statistical tests used were: unpaired t-test for two group-comparisons or chi-square test or One-Way analysis of variances (ANOVA) followed by an appropriate multiple comparison procedure for comparisons comprising more than two groups

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SGLT-2 inhibitors are antihyperglycemic agents that target SGLT-2 proteins expressed in the proximal convoluted tubules of the kidneys, where they normally mediate the reabsorption of glucose from the urine

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