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In conclusion, E3 Ub-protein ligase is involved in processes such as inflammatory response and injury in podocytes, renal tubular epithelial cells, and glomerular mesangial cells by affecting the activity of multiple signaling pathways ( Table 1 ) ( Figure 2 )

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The findings continue to be discussed and interpreted, with the interpretation of the breadth of the gene-expression effects an area where the literature has been more descriptive than mechanistically resolved