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Group I (10 patients) applied glutathione (2%) cream to the right side of the face while placebo cream to the left side (as a control) twice daily for 10 weeks

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Studies by Willox and Royle have shown that only when the NTD is removed, a reduction in Transferrin uptake is observed 20

Therefore, it is reasonable using supplementation of liposomal glutathione, instead of the N-acetylcysteine or bonded cysteine utilized as precursors for GSH cell synthesis, since patients with deficient levels of glutamate-cysteine ligase and GSH synthetase will not be able to use N-acetylcysteine or bonded cysteine as substrates to synthesize their own GSH