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However, using a proteomic approach on a subset of placental samples, numerous mitochondrial proteins were found to be down-regulated in PE3 placentas compared with controls, including: subunits of OXPHOS protein complexes (NADH:Ubiquinone Oxidoreductase Subunit V3 [NDUFV3], Ubiquinol-Cytochrome C Reductase Core Protein 1 [UQCRC1], and UQCR Rieske Iron-Sulfur Polypeptide 1[UQCRFS1]), and proteins that affect mitochondrial dynamics (optic atrophy type 1 [OPA1]), mitochondrial import (TOMM7), and mitochondrial translation (mitochondrial ribosomal proteins, MRPS36, MRPL44, MRPS36, MRPL22, MRPL1), among others (Fig 1H)

The quantity on the label refers to the total amount of product inside each vial, unless otherwise noted

Step 3 Dose Dose amount per injection

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