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CHAC1, an enzyme that degrades GSH, is upregulated during cystine deprivation through the activation of the GCN2-eIF2-ATF4 pathway, enhancing ferroptosis onset

Additionally, the loss of muscle mass has been problematic for some individuals taking this class of medication, with lean body mass accounting for up to 1540% of total weight loss

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Kleinschnitz C, Stoll G, Bendszus M et al (2006) Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis