More than half of participants achieved at least 20% body weight loss
Seek urgent medical attention if you experience: Severe or persistent abdominal pain, particularly if it radiates to your back this may indicate pancreatitis or gallbladder disease, which have been associated with GLP-1 receptor agonist class medicines [16] [17] Persistent vomiting or an inability to keep fluids down, which may lead to dehydration Yellowing of the skin or eyes, or dark urine (possible signs of liver or gallbladder problems) Signs of a serious allergic reaction, such as facial swelling, difficulty breathing, or a widespread rash Contact your prescriber or trial team if: Hunger is severe, persistent, and significantly interfering with your ability to adhere to the treatment plan You are experiencing rapid or unexpected weight gain despite taking the medication as prescribed You notice symptoms that may suggest hypoglycaemia (low blood sugar), such as shakiness, sweating, confusion, or palpitations
Clinical trial participants should contact their trial coordinator immediately
Overlooking compounding pharmacies
Insulin resistance may alter insulin signalling pathway within myocardial cells to cause heart failure, stroke and myocardial dysfunction [92]
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