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Severe AP is characterized by impaired autophagic flux with accumulation of large autophagosomes and overloaded lysosomes, leading to the persistence of dysfunctional mitochondria, excess mtROS, and the release of mitochondrial DAMPs

and 2022ZD0213000 to F.Z.)

Nature 566:496502 Carretero R, Sektioglu IM, Garbi N, Salgado OC, Beckhove P, Hammerling GJ (2015) Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8(+) T cells

The infiltration of eosinophils increases and contributes to liver regeneration following PHx

Vaginal estrogen therapy, which delivers estrogen locally without significant systemic absorption, is one of the most effective treatments for recurrent UTIs in postmenopausal women