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This temporary dysfunction triggers an energy crisis in the brain, as blood flow and oxygen levels drop while inflammation increases

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Common side effects may include: Nausea Diarrhea or constipation Heartburn or indigestion Decreased appetite (which is also the intended effect) Fatigue For many, these symptoms are mild and fade as the body adjusts

Characteristics Mechanism Methotrexate primarily inhibits dihydrofolate reductase (DHFR), an enzyme crucial for converting dihydrofolate to tetrahydrofolate, which is necessary for nucleotide synthesis