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Access to treatment then comes down to families who can afford to pay for it out-of-pocket, which creates an equity issue and forces children who could benefit the most from intervention to stop, Shah said

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For example, in one cohort study of 125,474 patients (without type 2 diabetes) who initiated GLP-1s, 46.5% discontinued use within one year

Procedures such as sleeve gastrectomy and Roux-en-Y gastric bypass produce average weight reductions of 25 to 35% and remain the most durable interventions available for severe obesity and obesity-related metabolic disease