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Compounded semaglutide is prepared by licensed 503A compounding pharmacies using USP-grade semaglutide powder or bulk chemical, compounded to patient specifications under state pharmacy board oversight and DEA regulation

Among 298 patients who were diagnosed with an ORC during the follow-up period, 77 (26 percent) were diagnosed with breast cancer, 49 (16 percent) were diagnosed with colon or rectum cancer, and 45 (15 percent) were diagnosed with uterine cancer

[16] [17] Whether these risks apply to retatrutide specifically is not yet established, as the full long-term safety profile remains unknown pending Phase 3 data

10.1126/science.1059780 97 MaL.GaoY.ChenJ.HaiD.YuJ.TangS.et al (2025)