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For example, a narrative review 3 acknowledged the peptides high safety profile: LD1 not achieved in humantranslatable data and no serious adverse effects reported in the available human usage context

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Increased endocannabinoids inhibit monoacylglycerol lipase (Alhouayek et al., 2011), thereby reducing systemic inflammation, altering intestinal peptide secretion and increasing intestinal mucosal barrier thickness