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In a study of 37 eyes by Shields et al

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Abbreviations ACE: Angiotensin-converting enzyme DPP-IV: Dipeptidyl peptidase IV X-Hyp: X-hydroxyproline X-Hyp-Gly: X-hydroxyproline-glycine Gly-X-Y: Glycine-XY Pro: Proline Hyp: Hydroxyproline Tyr: Tyrosine Trp: Tryptophan Phe: Phenylalanine His: Histidine Met: Methionine Glu: Glutamine Hyp: Hydroxyproline ROS: Reactive oxygen species SOD: Superoxide dismutase CAT: Catalase GSH: Glutathione Zn 2 : Zinc ion Val: Valine GIP: Glucose-dependent insulinotropic peptide GLP-1: Glucagon peptide-1 T2DM: Type 2 diabetes GPCRs: G-protein coupled receptors Ser: Serine References Granato D, Barba FJ, Bursa Kovaevi D, Lorenzo JM, Cruz AG, Putnik P

CONTRA-INDICATIONS Hypersensitivity to piperazine